| S 350 d (223.130) | 210 | 286 | 09-2020/ - | |
| S 350 d 4-matic (223.131) | 210 | 286 | 09-2020/ - | |
| S 350 d Mild Hybrid (223.120) | 230 | 313 | 05-2023/ - | |
| S 350 d Mild Hybrid 4-matic (223.121) | 230 | 313 | 05-2023/ - | |
| S 400 d 4-matic (223.133) | 243 | 330 | 09-2020/ - | |
| S 400 EQ Boost (223.157) | 230 | 313 | 08-2021/ - | |
| S 400 EQ Boost (223.159) | 230 | 313 | 01-2021/ - | |
| S 450 d Mild Hybrid 4-matic (223.123) | 270 | 367 | 05-2023/ - | |
| S 450 e (223.166) | 300 | 408 | 05-2022/ - | |
| S 450 EQ Boost (223.155) | 270 | 367 | 08-2021/ - | |
| S 450 EQ Boost (223.160) | 270 | 367 | 07-2021/ - | |
| S 450 EQ Boost 4-matic (223.156) | 270 | 367 | 08-2021/ - | |
| S 450 EQ Boost 4-matic (223.161) | 270 | 367 | 10-2020/ - | |
| S 450 EQ Boost 4-matic (223.161) | 280 | 381 | 09-2022/ - | |
| S 500 EQ Boost 4-matic (223.163) | 320 | 435 | 09-2020/ - | |
| S 500 EQ Boost 4-matic (223.163) | 330 | 449 | 09-2022/ - | |
| S 580 4-matic (223.176) | 370 | 503 | 05-2021/ - | |
| S 580 e (223.168) | 270 | 367 | 07-2021/ - | |
| S 580 e (223.168) | 375 | 510 | 07-2021/ - | |
| S 580 e 4-matic (223.169) | 375 | 510 | 07-2021/ - | |
| S 63 AMG Hybrid 4-matic (223.182) | 590 | 802 | 05-2023/ - | |